|
KMID : 0545120010110030463
|
|
Journal of Microbiology and Biotechnology
2001 Volume.11 No. 3 p.463 ~ p.468
|
|
|
Inclusion Complexation of a Family of Cyclosophoraoses with Indomethacin
|
|
Lee, Sang Hoo
Kwon, Chan Ho/Choi, Young Jin/Seo, Dong Hyuk/Kim, Hyun Won/Jung, Seun Ho
|
|
|
Abstract
|
|
|
|
Cyclosophoraoses are a class of unbranched cyclic-(1→2)-β-D-glucans found in the Rhizobium species. Their unique cyclic structures and high solubility make them potent for inclusion complexation as a host for an insoluble guest molecule. A family of neutral cyclosophoraoses (DP 17-27) isolated from Rhizobium meliloti 2011 was used as a host for inclusion complexation with an insoluble guest drug, indomethacin. A high performance liquid chromatographic analysis indicated that the inclusion complexation of cyclosophoraoses greatly enhanced the solubility of indomethacin compared with β-cyclodextrin. The estimated value of the association constant of the complex in water for β-cyclodextrin and cyclosophoraoses was 523M^-1 and 17,570M^-1, respectively. NMR spectroscopy showed that the inclusion complex was characterized by the interaction of the indole ring moiety of indomethacin with the cavity of cyclosophoraoses.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|